Synthesis and Biological Evaluation of Bioactive 5-Bromo-2- Hydroxy-4-Chloro Substituted Ketimines
1Ganesh Andhale*, 2 Sanghapal Paden, 3 Prabhakar Kute & 4Satyanarayan Arde
1Department of Chemistry Shri Shivaji Arts, Commerce & Science College Akot. Dist. Akola Maharashtra 444101
2Rajarshi Shau Science College Chandur Railway, Dist Amravati Maharashtra 444101
3Department of Chemistry, Pratishthan Mahavidylaya, Paithan, Dist. Sambhaji Nagar (M.S.) 431107
4Department of Chemistry Y.C. Warana Mahavidyalaya, Warananagar (M.S.) 416113 India.
ganeshandhale005@gmail.com
ABSTRACT:
Ketimines exhibit a wide range of biological activities such as antibacterial, antifungal, anti-inflammatory, antiviral and antipyretics. Ketimines or azomethine which are analogue of aldehyde or ketone in which carbonyl group (C=O) replaced by azomethine (C=N) group. This class of organic compounds has great importance in the field of coordination chemistry because of potentially capable of forming stable complexes with metal ions. Fast and very rapid procedure is reported for the synthesis of 2-hydroxy-5-bromo-n-(substituted-phenyl)-ketimines from substituted 2-hydroxychalcone and different substituted aromatic amines under 10% ethanol suspension. The study of imine metal complexes is very interesting because of their unusual stability, sensitivity, selectivity, chemical and magnetic properties. The chemical and biological importance of azomethine (C=N) group is due to presence of lone pair in sp2 hybridized orbital which make them a good chelating agents. Generally the bi and tri dentate ligands are more capable of forming stable complexes with S and D block elements. Therefore imine metal complexes were significantly investigated for their antifungal, antibacterial, antimicrobial, antitumor and enzymatic activities.
DOI link – https://doi.org/10.69758/GIMRJ/2504I5VXIIIP0064
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