SOLVENT EFFECTS ON THE PHYSICO-CHEMICAL BEHAVIOR OF 1-((4-METHOXY-3, 5-DIMETHYLPYRIDIN-2-YL) METHYL)-3-PHENYLTHIOUREA IN 40% ETHANOL-WATER SOLUTIONS
R.D. More1, P.R. Kute2*, A.O.Dhokte2, G.B. Andhale3, N.D.Chaudhari4, S.U Shinde4 R.D.Pathrikar5
1Department of Chemistry, Siddharth Arts, Commerce and Science College, Jafrabad, Dist. Jalna (MS), India.
2*Department of Chemistry, Pratishthan Mahavidyalaya, Paithan, Dist.-Chh. Sambhajinagar, (MS), India.
3Department of Chemistry, Shri Shivaji Arts, Commerce and Science College Akot,Maharashtra, India
4Department of Chemistry, Pratishthan Mahavidyalaya, Paithan, Dist.-Chh. Sambhajinagar, (MS), India.
4Department of Chemistry, Rajaeshi Shahu College Pathri. Dist.-Chh. Sambhajinagar, (MS), India.
2*Email: – kuteprabhakar@gmail.com
ABSTRACT
Heterocyclic molecules play a crucial role in medicinal chemistry, serving as the structural backbone for many pharmaceutical drugs. Pyridine, a six-membered heteroaromatic ring, is an essential component of various natural compounds, such as vitamins and alkaloids, and its derivatives are widely recognized for their adaptability in drug design. In a recent study conducted in our laboratory, we investigated the viscosity and density of 1-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-3-phenylthiourea across different concentrations and temperature conditions. The experimental results provided significant insights into solute-solvent interactions and the influence of solvent dilution. The findings revealed that as temperature increases, relative viscosity decreases, indicating enhanced solvation effects. This research enhances the understanding of the physicochemical properties of pyridine derivatives, supporting the development of more efficient pharmaceutical compounds.
Keywords: Heterocyclic, pyridine, Viscosity, Density, Medicinal, Solute-solvent interactions, 1-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-3-phenylthiourea,etc.
DOI link – https://doi.org/10.69758/GIMRJ/2504I5VXIIIP0031
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