Organ Transplant and Challenges
Dr. Varsha Deshmukh,
Principal, Dr. Panjabrao Deshmukh
College of Law, Amravati
imageamt.vd@gmail.com, 9970173876
Abstract:
In the 1950s, the first attempts at immunosuppression for kidney transplantation involved total irradiation and was met with some degree of success The use of chemical immunosuppression, initially with 6-mercaptopurine and then with combination of azathioprine and steroids, avoided the problems associated with irradiation and improved outcomes significantly. It was the discovery of cyclosporine in 1976, and its introduction in clinical practice in 1984, that dramatically changed the landscape of OT(Organ Transplant) resulting in an increased one-year survival in both kidney and liver transplant recipients (95 and 75% respectively). Modern immunosuppressive agents (tacrolimus, sirolimis, mycophenolic acid, and everolimus), allow us to currently enjoy superior outcomes and a reduction in adverse immunosuppressive effects.
The next important milestone in the development of OT was the founding of the United Network of Organ Sharing (UNOS) in 1984. This organization manages all transplant activities in the US including the maintenance of a national transplant list for all types of transplantation, data collection, and coordination of educational activities. There are a number of organizations in Europe and Asia with similar responsibilities.
Doi Link – https://doi.org/10.69758/GIMRJ2407IIIIV12P0010
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