KPS as an Eco-Friendly Oxidant for synthesis of dibenzo [b, e] [1,4] diazepine derivatives through intermolecular radical cyclization in aqueous solution
Asghar Jafar khan1 and Abdul Rahim Abdul Sami*1
1. Organic Chemistry Laboratory, Milliya College, Beed-431122, [MS], India.
*Corresponding Author: phychemmax@gmail.com, khan_asgar@yahoo.com
ABSTRACT:
Bio active dibenzo [b, e] [1,4] diazepine derivatives have been synthesised by Potassium Persulfate as an eco-friendly oxidant for Oxidative Transformations. This type of reaction likely involves the nucleophilic attack of the amine group on the carbonyl group of the aldehyde, followed by cyclization to form the diazepine ring. This kind of reaction is particularly useful in creating complex heterocyclic structures, which are important in the development of biologically active compounds. Dibenzo [b, e] [1,4] diazepine derivatives were efficiently and easily synthesised by addition/cyclisation of compounds o-phenylenediamine with substituted o-Chloro benzaldehyde, K2CO3over KPS (25 mol%)with high efficiency in water as a green solvent at 80 °C. The synthesized compounds were characterized by 1H NMR, Mass and IR spectral analysis.
Keywords: KPS [Potassium persulfate], K2CO3, dibenzo [b,e] [1,4] diazepine derivatives ,substituted aromatic aldehydes,o-phenylenediamine(OPD).
DOI link – https://doi.org/10.69758/GIMRJ/2504I5VXIIIP0052
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